Changes in version 2.1.1 (2017-08-11)                  

    o   Update trtsel man files specifying that larger values of a continuous outcome should be associated with worse outcomes. 

                 Changes in version 2.1.0 (2017-07-25)                  

Two key additions: 

    o   allow continuous and time-to-event outcomes 

    o   allow a user to evaluate models with more than one marker

One minor additions: 

    o   updated the estimator of event rate under marker based treatment. 

                        Changes in version 2.0.4                        

    o   adjusted estimate of event rate under marker-based trt. 

                 Changes in version 2.0.3 (2017-02-09)                  

Note: This is a large update with many changes. Although, the estimation methods remain the same, many of the functions inputs have changed. This is to accomodate multivariate models and survival outcomes. 

    o   Addition of 'trtsel_measures': a simple function for evaluating the performance of a user-specified marker-based treatment rule.

    o   Input formulas into trtsel objects instead of univariate marker information. This allows for the evaluation of multivariate models. 

    o   The package now allows for survival outcomes.

    o   Bias-correction to adjust for over-optimism that comes from evaluating models on the same data that were used to fit model parameters. `eval.trtsel` and `compare.trtsel` now implements a bootstrap bias-correction method. 

                        Changes in version 1.1.3                        

    o   tweaked estimation of Var(Delta) for subcohort designs. 

                 Changes in version 1.1.2 (2014-06-17)                  

    o   added plot.type 'selection impact'. see ?plot.trtsel for more information. 

    o   fixed a small bug that caused warnings when plotting a trtsel object created from providing fixed risk estimates. 

                 Changes in version 1.1.1 (2014-04-07)                  

    o   eval.trtsel: modeled estimates of event rates calculated for subcohort designs had a bug. Calculations now are correct. 

    o   eval.trtsel:  also fixed bug where event rates werent calculated when bootstraps = 0. 

    o   eval.trtsel:  fixed event rate labeling bug that swapped trt all for trt none. 

    o   plot.trtsel: added new plot.type that plots event rate under different marker based treatment assignment rules vs. F_delta(v).

    o   plot.trtsel:  the mean trt effect line for subcohort designs was not weighted correctly. this has been fixed for continuous and discrete markers. 

    o   plot.trtsel:  fixed a bug building plots for subcohort designs with discrete markers 

    o   fixed various small things so that the package now has no warnings from R CMD Check

    o   added manual files for tsdata_scc and tsdata_cc

    o   calibrate.trtsel: fixed bug when calibrating models fit using stratified case-control data.